Mosquitoes in search of blood as well as fruit flies looking for a place to lay their eggs navigate using CO₂, which is produced during respiration or in fermentation processes. A complex of various odor receptors that can detect CO₂ has already been identified in mosquitoes. Researchers at Ruhr University Bochum, Germany, have now shown that individual receptors found in fruit flies can also detect CO₂. They also identified molecules that blocked the CO₂ receptors. In mosquitoes, a receptor complex containing among others the receptors Gr21a and Gr63a is responsible for CO₂ detection. However, it was unclear whether CO₂ binds directly to the receptors or whether CO₂ sensitivity results from the interaction with other proteins.

The researchers injected the isolated receptors into frog egg cells. Using electrophysiological measurements, they recorded the response of the receptors when they came into contact with CO₂. They demonstrated in the process that individually Gr21a and Gr63a can detect the CO₂ molecule directly, albeit somewhat less effectively than when embedded in a protein complex. Citronellol blocks receptors. In addition to already known blockers, the researchers discovered that the substance citronellol suppresses the ability of the Gr21a and Gr63a receptors to detect CO₂. Citronellol is found in a number of insect repellents. It could make you virtually invisible to mosquitoes.

The new findings are to be incorporated into the development of a CO₂ biosensor, which the Bochum team is researching in cooperation with the Institute of Aircraft Systems in Stuttgart. "This should enable us to detect CO₂ in liquid media, which is something that as yet can't be done," says Störtkuhl. CO₂ sensors are used on the International Space Station, for example, where they must consume as little energy as possible. Given that physical measurement methods are not very energy-efficient, a biosensor could be a great alternative. It may also be possible to detect other volatile substances with the sensor in the future.