Scientific Review

Comparative Analysis of Dengue and Zika Virus Transmissibility in Primates  

Jia Xuan
Institute of Life Science, Jiyang College of Zhejiang A&F University, Zhuji, 311800, China
Author    Correspondence author
Journal of Mosquito Research, 2024, Vol. 14, No. 1   doi: 10.5376/jmr.2024.14.0003
Received: 27 Mar., 2024    Accepted: 01 Apr., 2024    Published: 05 Apr., 2024
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Preferred citation for this article:

Xuan J., 2024, Comparative analysis of dengue and zika virus transmissibility in primates, Journal of Mosquito Research, 14(1): 18-25 (doi: 10.5376/jmr.2024.14.0003)


The paper "Trade-offs shaping transmission of sylvatic dengue and Zika viruses in monkey hosts" authored by Kathryn A. Hanley, Hélène Cecilia, Sasha R. Azar, et al., was published in Nature Communications on March 27, 2024. The authors are affiliated with Department of Biology, New Mexico State University, Department of Pathology, University of Texas Medical School, among other institutions. This study explores the factors affecting the transmission of Dengue (DENV) and Zika (ZIKV) viruses in monkey hosts. By experimentally infecting Asian ancestral host species (rhesus monkeys) and a New World host species (squirrel monkeys), the study investigated viral replication, innate and adaptive immune responses (natural killer cells and neutralizing antibodies), and transmission to mosquitoes. Results show that ZIKV reached high titers in both hosts and translated to high mosquito transmission rates; in contrast, DENV-2 had lower replication levels, with transmission occurring only when serum viral titers were below or near the detection limit. The study reveals the immune-mediated trade-offs between the duration and intensity of viral replication.

Dengue; Zika Virus
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