Ana Cristina Silva Pinto¹ , Karla Lagos Nogueira¹ , Francisco Celio Maia Chaves² , Luis Vilmar Souza da Silva³ , Wanderli Pedro Tadei¹ , Adrian Martin Pohlit⁴

1. Laboratory of Malaria and Dengue, Department of Society, Environment and Health, National Institute of Amazonian Research (INPA), Brazil
2. Embrapa Western Amazon; Vegetable and Medicinal Plant, Production Systems, AM Route 010, Km 29, 69010-970, Manaus, AM, Brazil
3. Laboratory of Water Resources, Department of Environmental Dynamics, INPA, Brazil
4. Laboratory of Active Principles of the Amazon (LAPAAM), Department of Technology and Innovation, INPA, Avenida Andre Araujo, 2936, 69060-001, Manaus, AM, Brazil
Author    Correspondence author
Journal of Mosquito Research, 2012, Vol. 2, No. 1   doi: 10.5376/jmr.2012.01.0001
Received: 15 Jun., 2012    Accepted: 04 Jul., 2012    Published: 28 Aug., 2012

This is an open access article published under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Pinto et al., 2012, Adulticidal Activity of Dillapiol and Semi-synthetic Derivatives of Dillapiol against Aedes aegypti (L.) (Culicidae), Journal of Mosquito Research, Vol.2, No.1 1-7 (doi: 10.5376/jmr.2012.01.0001)

Phenylpropanoid dillapiol (1) isolated from the essential oil in leaves of Piper aduncum L. and thirteen semi-synthetic, C₃ side-chain modified dillapiol derivatives 2-14 were evaluated for lethality against hemorrhagic dengue fever mosquito vector Aedes aegypti L.. First, adult female mosquitoes were exposed to these substances in a contact bioassay carried out in glass bottles at a single surface density (0.57 µg/cm²). Then, median lethal concentrations (LC₅₀) and LC₉₀ were determined for active compounds. It was found that the structure of the C₃ side chain was important for the toxic effects of these substances against A. aegypti adult females. Isodillapiol (2) and methyl, propyl and butyl 1-(2´,3´-dimethoxy-4´,5´-methylenedioxyphenyl)propan-2-yl ethers (3, 5 and 6, respectively) all exhibited greater mosquitocidal activity than dillapiol (1). The order of molar per surface area of mosquitocidal activities was isodillapiol (2) > butyl ether 6 > methyl ether 3 > propyl ether 5 > dillapiol (1). The potential of dillapiol and derivatives as A. aegypti mosquitocides was discussed.

Mosquitocidal activity; Aedes aegypti; Isodillapiol; 2-methoxy dillapiol; 2-ethoxy dillapiol; 2-n-propoxy dillapiol; 2-n-butoxy dillapiol