Fangya Chen Fangya Chen

Tropical Animal Resources Research Center, Hainan Institute of Tropical Agricultural Resources, Sanya, 572000, Hainan, China
Author    Correspondence author
Journal of Mosquito Research, 2024, Vol. 14, No. 6   
Received: 11 Oct., 2024    Accepted: 20 Nov., 2024    Published: 02 Apr., 2025

This is an open access article published under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Mosquito-borne diseases, such as malaria, dengue, and Zika, pose a significant global health threat due to their widespread prevalence and severe consequences. This study investigates the intricate mechanisms of human immune responses to mosquito-borne pathogens, focusing on both innate and adaptive immunity. The role of pattern recognition receptors, inflammatory pathways, and cytokine signaling in initial pathogen detection is explored, alongside the limitations of innate immunity. The adaptive immune response, encompassing B cell-mediated antibody production and T cell functionality, is analyzed, with attention to the challenges posed by immunopathology. A case study on Plasmodium highlights the immune evasion strategies employed by pathogens, emphasizing antigenic variation and immune suppression. The implications of these findings for vaccine development and therapeutic interventions are discussed, underscoring current progress and challenges in achieving long-term immunity. Finally, the study identifies future research directions, advocating for systems immunology and innovative technologies to enhance our understanding of host-pathogen interactions. This research provides a comprehensive framework for leveraging immune responses in combating mosquito-borne diseases and improving global health outcomes.

Mosquito-borne diseases; Immune response; Pathogen evasion; Vaccine development; Systems immunology