Jie Zhang

Institute of Life Science, Jiyang College of Zhejiang AandF University, Zhuji, 311800, Zhejiang, China
Author    Correspondence author
Journal of Mosquito Research, 2024, Vol. 14, No. 5   doi: 10.5376/jmr.2024.14.0025
Received: 11 Sep., 2024    Accepted: 13 Oct., 2024    Published: 26 Oct., 2024

This is an open access article published under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Zhang J., 2024, Vaccine strategies for yellow fever: current status and future directions, Journal of Mosquito Research, 14(5): 264-275 (doi: 10.5376/jmr.2024.14.0025)

This study explores the current status and future directions of yellow fever vaccines. Despite the availability of an effective live attenuated vaccine, challenges such as vaccine shortages, rare adverse reactions, and insufficient vaccination coverage remain major obstacles to controlling yellow fever. This study reviews the advantages and disadvantages of live attenuated vaccines, inactivated vaccines, and emerging DNA and RNA vaccines, highlighting the potential of nanoparticle and Virus-Like Particle (VLP) platforms. An analysis of recent vaccination efforts in Nigeria and other yellow fever-endemic regions underscores the importance of integrating vaccination with vector control strategies. To address these challenges, the article suggests enhancing vaccine production capacity, developing safer next-generation vaccines, and improving vaccination rates through public education and policy support. This study also points out that future research should focus on the long-term efficacy of fractional-dose vaccines and the development of multivalent vaccines to address the threat of multiple arboviruses.

Yellow fever vaccine; Live attenuated vaccine; DNA vaccine; RNA vaccine; Nanoparticle vaccine