Systematic Review

Functional Genomics of Mosquito Vector Competence and Pathogen Transmission  

Zixuan Zhao
Puji Biotechnology (Taizhou) Co., Ltd., Taizhou, 318000, Zhejiang, China
Author    Correspondence author
Journal of Mosquito Research, 2024, Vol. 14, No. 2   doi: 10.5376/jmr.2024.14.0009
Received: 16 Jan., 2024    Accepted: 26 Feb., 2024    Published: 16 Mar., 2024
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This is an open access article published under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Preferred citation for this article:

Zhao Z.X., 2024, Functional genomics of mosquito vector competence and pathogen transmission, Journal of Mosquito Research, 14(2): 76-86 (doi: 10.5376/jmr.2024.14.0009)


The primary objective of this study is to provide an in-depth overview of the functional genomics that underlie mosquito vector competence and the transmission of pathogens. The study integrates recent advancements and systematic analyses to elucidate the complex genetic and biochemical interactions that define how mosquitoes interact with and transmit pathogens. We highlight key genetic determinants of vector competence, demonstrating how specific genes and genomic configurations influence the ability of mosquitoes to acquire, sustain, and transmit a range of pathogens. The interactions between mosquito vectors and pathogens are explored, with an emphasis on how these relationships are mediated by genetic factors and influenced by external environmental conditions. Additionally, the study discusses the role of advanced genomic technologies, such as CRISPR/Cas9, RNA interference (RNAi), and high-throughput sequencing, which have been pivotal in dissecting these interactions and developing potential vector control strategies. Overall, the findings presented in this study enhance our understanding of the genetic mechanisms underpinning pathogen transmission by mosquitoes and lay the groundwork for future research aimed at disrupting these processes to reduce the prevalence of mosquito-borne diseases.

Mosquito vector competence; Pathogen transmission; Functional genomics; Genetic determinants; Genomic technologies
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