Scientific Review

Genetic Decoding of the African Malaria Mosquito Olfactory System: New Insights into Responses to Human Odors  

Tongtong Xu
Laboratory of Insect Breeding and Life Testing, Cuixi Academy of Biotechnology, Zhuji, 311800, China
Author    Correspondence author
Journal of Mosquito Research, 2024, Vol. 14, No. 2   doi: 10.5376/jmr.2024.14.0007
Received: 04 Apr., 2024    Accepted: 11 Apr., 2024    Published: 16 Apr., 2024
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This is an open access article published under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Preferred citation for this article:

Xu T.T., 2024, Genetic decoding of the african malaria mosquito olfactory system: new insights into responses to human odors, Journal of Mosquito Research, 14(2): 61-66 (doi: 10.5376/jmr.2024.14.0007)


The paper "An expanded neurogenetic toolkit to decode olfaction in the African malaria mosquito Anopheles gambiae," authored by Diego Giraldo, Andrew M. Hammond, Jinling Wu, et al., was published in Cell Reports Methods on March 27, 2024, from institutions such as Johns Hopkins Malaria Research Institute, Johns Hopkins Bloomberg School of Public Health, and Department of Life Sciences, Imperial College London. In this research, Giraldo and colleagues developed a neurogenetic toolkit to decode the olfactory system of the African malaria mosquito, Anopheles gambiae. By creating cell-type-specific driver lines, the research team successfully encoded genetic access to specific olfactory sensory neuron populations and validated the application of these tools in decoding mosquito responses to human odors. The method integrates the driver-responder-marker (DRM) system using CRISPR-Cas9 technology, thereby enabling rapid identification of the expression patterns of target chemoreceptor genes by screening GFP+ olfactory sensory neurons.

Genetic Decoding; African Malaria; Olfactory System
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