Review and Progress

The Method and Prospects of Changing Mosquito Genes with CRISPR-Cas9  

Mengyi Xu
Cuixi Biotechnology Research Institute, Zhuji, 311800, China
Author    Correspondence author
Journal of Mosquito Research, 2023, Vol. 13, No. 2   doi: 10.5376/jmr.2023.13.0002
Received: 15 Nov., 2023    Accepted: 22 Nov., 2023    Published: 04 Dec., 2023
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This is an open access article published under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Preferred citation for this article:

Xu M.Y., 2023, The method and prospects of changing mosquito genes with CRISPR-Cas9, Journal of Mosquito Research, 13(2): 1-8 (doi: 10.5376/jmr.2023.13.0002)


CRISPR-Cas9 technology, as a precise and efficient gene editing tool, has attracted much attention in the field of mosquito gene editing. The aim of this review is to explore the potential of CRISPR-Cas9 application in mosquito gene editing, the challenges and the importance of environmental health balance. This review discusses how this technology can provide new strategies for controlling mosquito-borne diseases, such as modulating antiviral genes and reproductive capacity, through targeted editing of mosquito genes, and also recognizes technical challenges such as guide RNA design and non-targeted editing, as well as ecological risks that may be triggered by editing. Against this background, this review emphasizes the need to balance scientific and technological development with environmental health to ensure that the application of editing technologies does not cause irreversible impacts on the environment and ecosystems, and that while advancing scientific and technological progress, the balance between technological development and environmental health must be carefully weighed in order to achieve the dual goals of human health and ecological sustainability.

CRISPR-Cas9; Mosquito gene editing; Gene alteration; Disease control
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