Research Article

Research on Insect Pathogen Resistance Based on GWAS: Methods, Challenges, and Prospects  

Fangqi Xu
Insect Breeding and Biotesting Laboratory, Cuixi Academy of Biotechnology, Zhuji, 311800, China
Author    Correspondence author
Molecular Entomology, 2024, Vol. 15, No. 1   doi: 10.5376/me.2024.15.0002
Received: 14 Nov., 2023    Accepted: 24 Dec., 2023    Published: 14 Jan., 2024
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This is an open access article published under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Preferred citation for this article:

Xu F.Q., 2024, Research on insect pathogen resistance based on GWAS: methods, challenges, and prospects, Molecular Entomology, 15(1): 8-17 (doi: 10.5376/me.2024.15.0002)


This study reviews the application of genome-wide association studies (GWAS) in the field of insect pathogen resistance, and discusses the main methods, challenges, and future development prospects of this research direction. This study introduces the basic principles of GWAS and its application in revealing the genetic basis of insect resistance to pathogens. By analyzing genetic variations in the insect genome, GWAS helps scientists identify key genes and functional regions related to resistance. This study discusses the main challenges encountered in conducting GWAS research, including sample size limitations, genetic diversity, environmental factors, and difficulties in detecting rare variations. It also explores issues such as data sharing and privacy protection. This study looks forward to the potential of utilizing GWAS results to improve insect resistance strategies, including the application of gene editing techniques such as CRISPR-Cas9 in insect resistance improvement, and emphasizes the importance of interdisciplinary collaboration in solving complex scientific problems. This study aims to provide a comprehensive perspective for the research and management of insect pathogen resistance, promoting scientific progress and technological innovation in related fields.

Genome-wide association studies; Insect resistance; Gene editing technology; Interdisciplinary cooperation; Pathogen control
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